ncRNA name | MITF siRNA |
ncRNA Category | siRNA |
Disease name | proliferative vitreoretinopathy (PVR) |
Species | Homo sapiens |
Tissues/Cell_line | human fetal RPE cells, human fetal choroidal fibroblast cells |
Methods | siRNA transfection, Western blot, immunofluorescence |
Expression pattern | associated |
Functional description | Microphthalmia-associated transcription factor (MITF) is a key regulator of RPE differentiation that was also down-regulated in dedifferentiated hfRPE cells. MITF knockdown decreased miR-204/211 expression and caused hfRPE dedifferentiation. Significantly, co-transfection of MITF siRNA with pre-miR-204/211 rescued RPE phenotype. |
PubMed ID | 22523078 |
Year | 2012 |
Title | Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression. |
Drug-related ncRNA | NO |
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